Krone W, Jirikowski G, Mühleck O, Kling H, Gall H
Hum Genet. 1983;63(3):247-51. doi: 10.1007/BF00284658.
The occurrence of glial cells in primary cultures established from peripheral neurofibromas of 18 patients with neurofibromatosis (von Recklinghausen) is described. The spindle-shaped cells can be distinguished from fibroblasts on the basis of morphological and ultrastructural criteria. As demonstrated by immunocytochemical analysis, the spindle cells express S-100 protein. Neither glial fibrillar acidic protein nor myelin basic protein can be detected in these cells. In many respects the spindle cells resemble immature Schwann cells in culture.
本文描述了从18例神经纤维瘤病（冯·雷克林豪森病）患者的外周神经纤维瘤建立的原代培养物中神经胶质细胞的出现情况。根据形态学和超微结构标准，可将梭形细胞与成纤维细胞区分开来。免疫细胞化学分析表明，梭形细胞表达S-100蛋白。在这些细胞中未检测到胶质纤维酸性蛋白和髓鞘碱性蛋白。在许多方面，梭形细胞类似于培养中的未成熟雪旺细胞。
