Krone W, Högemann I
Hum Genet. 1986 Dec;74(4):453-5. doi: 10.1007/BF00280506.
Cell cultures grown from peripheral neurofibromas of three patients suffering from sporadic peripheral neurofibromatosis (NF) were analysed cytogenetically at early in vitro passages. The NF-cultures exhibited a 6.7-fold higher frequency of aneuploid mitoses, including pseudodiploids, than the control cultures derived from the skin of three healthy donors. The predominant numerical anomaly was monosomy 22. Several, as yet unidentified marker chromosomes occurred in the NF-cultures, which also showed a much higher level of unstable chromosomal anomalies. The role of monosomy 22 in tumorigenesis of meningiomas and neurofibromas is discussed.
对三名散发型周围神经纤维瘤病（NF）患者的周围神经纤维瘤所培养的细胞，在体外传代早期进行了细胞遗传学分析。与来自三名健康供体皮肤的对照培养物相比，NF培养物中包括假二倍体在内的非整倍体有丝分裂频率高6.7倍。主要的数目异常是22号染色体单体。NF培养物中出现了几条尚未鉴定的标记染色体，其不稳定染色体异常水平也高得多。讨论了22号染色体单体在脑膜瘤和神经纤维瘤肿瘤发生中的作用。
