Mühleck O, Krone W, Mao R, Weber L
Arch Dermatol Res. 1986;278(3):232-7. doi: 10.1007/BF00412930.
Comparative measurements of collagen synthesis as a portion of total protein synthesis were performed with fragments of peripheral neurofibromas, of skin adjacent to the tumors, and of unaffected skin from patients with neurofibromatosis (NF). No significant difference was found among these various samples. Collagen synthesis was also measured in cell cultures derived from peripheral neurofibromas of eight NF patients and from skin of ten healthy donors. No differences observed in the following respective parameters: dependence on the concentration of fetal calf serum; dependence on cell population density; portion of synthesized collagens in the culture medium and the cell layer. The ratios of synthesized collagen types III to type I, determined in five pairs of NF and control strains, vary within the same range.
对神经纤维瘤病（NF）患者的外周神经纤维瘤碎片、肿瘤旁皮肤以及未受影响的皮肤进行了胶原蛋白合成占总蛋白合成比例的比较测量。在这些不同样本之间未发现显著差异。还对来自8例NF患者外周神经纤维瘤和10例健康供体皮肤的细胞培养物中的胶原蛋白合成进行了测量。在以下各项参数中未观察到差异：对胎牛血清浓度的依赖性；对细胞群体密度的依赖性；培养基和细胞层中合成胶原蛋白的比例。在五对NF和对照菌株中测定的III型与I型合成胶原蛋白的比率在相同范围内变化。
