畸胎癌干细胞黏附：二价阳离子和一种细胞表面凝集素的作用
Teratocarcinoma stem cell adhesion: the role of divalent cations and a cell surface lectin.
作者信息
Grabel L B, Singer M S, Martin G R, Rosen S D
出版信息
J Cell Biol. 1983 Jun;96(6):1532-7. doi: 10.1083/jcb.96.6.1532.
Abstract
We describe two additive systems of intercellular adhesion in teratocarcinoma stem cells (Nulli cell line). One component is divalent cation-dependent (Ca++ or Mg++) and the other involves a cell surface fucan/mannan-specific lectin, previously identified on stem cells by an erythrocyte rosetting assay. The existence of these two systems is inferred from the observation that reaggregation of stem cells was partially inhibited by the removal of divalent cations or by the presence of lectin inhibitors such as fucoidan, but reaggregation was completely blocked when the two conditions were combined. Our results are related to recent work describing a calcium-dependent system of intercellular adhesion in teratocarcinoma stem cells.
摘要
我们描述了畸胎癌干细胞（Nulli细胞系）中两种细胞间黏附的加成系统。一种成分依赖二价阳离子（Ca++或Mg++），另一种涉及细胞表面岩藻聚糖/甘露聚糖特异性凝集素，此前通过红细胞花环试验在干细胞上鉴定出该凝集素。这两种系统的存在是基于以下观察结果推断出来的：去除二价阳离子或存在凝集素抑制剂（如岩藻依聚糖）时，干细胞的重新聚集受到部分抑制，但当两种条件同时存在时，重新聚集则完全被阻断。我们的结果与最近描述畸胎癌干细胞中钙依赖性细胞间黏附系统的研究相关。
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