Dackis C A, Bailey J, Pottash A L, Stuckey R F, Extein I L, Gold M S
Am J Psychiatry. 1984 May;141(5):680-3. doi: 10.1176/ajp.141.5.680.
The authors examined dexamethasone suppression test (DST) and thyrotropin-releasing hormone (TRH) test results in 32 chronic alcoholics without depression or hepatic disease to see if alcoholism alone might lead to positive test results. After 3 weeks of sobriety there were no DST abnormalities, but blunted TRH test results were observed in eight of the 32 alcoholics. More of the 15 patients also tested during alcohol withdrawal than of the 20 normal subjects or the 32 alcoholics without alcohol withdrawal had DST and TRH test abnormalities. When performed after 3 weeks of sobriety, the DST but not the TRH test has potential as a specific laboratory adjunct in the diagnosis of depression in alcoholics.
作者检测了32名无抑郁症或肝病的慢性酒精中毒者的地塞米松抑制试验（DST）和促甲状腺激素释放激素（TRH）试验结果，以探究仅酒精中毒是否可能导致试验结果呈阳性。戒酒3周后，未发现DST异常，但在32名酒精中毒者中有8人观察到TRH试验结果减弱。与20名正常受试者或32名未戒酒的酒精中毒者相比，15名在戒酒期间接受检测的患者出现DST和TRH试验异常的情况更多。在戒酒3周后进行检测时，DST而非TRH试验有潜力作为诊断酒精中毒者抑郁症的一种特定实验室辅助手段。
