Bretza J, Wells I, Novey H S
Am J Med. 1983 Jun;74(6):945-50. doi: 10.1016/0002-9343(83)90787-8.
The relationship between adverse reactions to chrysotherapy and specific IgE antibodies to sodium aurothiomalate (auIgE) was studied in 67 patients with rheumatoid arthritis (62) or psoriatic arthritis (5). Thirty patients (45 percent) had such antibodies versus none of the 27 control patients. Of the 34 patients in whom reactions to chrysotherapy developed, 23 (68 percent) had auIgE versus 7 (21 percent) without reactions (p less than 0.001). Mucocutaneous lesions were significantly associated with auIgE (p less than 0.001). All five patients with thrombocytopenia, but only one of five with the nephrotic syndrome, had auIgE. The patients with IgE response had higher total serum IgE levels (p less than 0.005), were more likely to be atopic (four to one), and had more recently received chrysotherapy (mean 2.8 +/- 1.95 years versus 7.0 +/- 5.75 years, p less than 0.001) than those without response, but did not differ by either the gold product or the total dose used. Chrysotherapy is associated with the production of specific IgE antibodies to a gold salt, and some mucocutaneous and hematologic reactions may be immunologically mediated.
对67例类风湿性关节炎患者（62例）或银屑病关节炎患者（5例），研究了金疗法不良反应与硫代苹果酸金钠特异性IgE抗体（auIgE）之间的关系。30例患者（45%）有此类抗体，而27例对照患者均无。在34例发生金疗法反应的患者中，23例（68%）有auIgE，无反应的7例患者中有2例（21%）有auIgE（p<0.001）。皮肤黏膜病变与auIgE显著相关（p<0.001）。所有5例血小板减少症患者均有auIgE，但5例肾病综合征患者中只有1例有auIgE。有IgE反应的患者血清总IgE水平较高（p<0.005），更可能是特应性体质（4比1），且比无反应的患者更近接受过金疗法（平均2.8±1.95年对7.0±5.75年，p<0.001），但在所用金制剂或总剂量方面无差异。金疗法与金盐特异性IgE抗体的产生有关，一些皮肤黏膜和血液学反应可能是免疫介导的。
