Weiss J W, Rossing T H, Ingram R H
Am Rev Respir Dis. 1983 Jun;127(6):705-8. doi: 10.1164/arrd.1983.127.6.705.
Seven patients receiving chronic ventilatory support were studied to better define the effects of intermittent mandatory ventilation (IMV) on the control and timing of spontaneous breathing between mandatory breaths. Each of these patients could sustain adequate spontaneous ventilation, as reflected by stable end-tidal carbon dioxide concentration (FETCO2), and arterial oxygen saturation (SO2) during periods of unassisted ventilation of sufficient duration to allow study. Inspiratory time (TI), respiratory cycle duration (Ttot), tidal volume (VT), and tracheal occlusion pressure (P0.1) were measured as IMV rate was progressively reduced. Respiratory timing was unaltered by decreasing IMV frequency; however, VT increased progressively. The P0.1 and mean inspiratory flow rate (VT/TI) also increased with each decrease in IMV rate, whereas FETCO2 and arterial SO2 remained constant. Thus, in these stable but ventilator-dependent patients, IMV did not alter respiratory timing or chemical stimuli, but it did alter respiratory drive as measured by VT/TI and P0.1.
对7名接受长期通气支持的患者进行了研究，以更好地确定间歇指令通气（IMV）对指令呼吸之间自主呼吸的控制和时间安排的影响。这些患者中的每一位在足够长的自主通气期间（足以进行研究），都能维持足够的自主通气，这通过稳定的呼气末二氧化碳浓度（FETCO2）和动脉血氧饱和度（SO2）得以体现。随着IMV频率逐渐降低，测量吸气时间（TI）、呼吸周期时长（Ttot）、潮气量（VT）和气管阻塞压（P0.1）。降低IMV频率并未改变呼吸时间安排；然而，潮气量逐渐增加。随着IMV频率每次降低，P0.1和平均吸气流量（VT/TI）也增加，而FETCO2和动脉SO2保持不变。因此，在这些病情稳定但依赖呼吸机的患者中，IMV并未改变呼吸时间安排或化学刺激，但确实改变了以VT/TI和P0.1衡量的呼吸驱动力。
