枯草芽孢杆菌的嘌呤补救途径及鸟嘌呤对GMP还原酶突变体生长的影响。
Purine salvage pathways of Bacillus subtilis and effect of guanine on growth of GMP reductase mutants.
作者信息
Endo T, Uratani B, Freese E
出版信息
J Bacteriol. 1983 Jul;155(1):169-79. doi: 10.1128/jb.155.1.169-179.1983.
Abstract
We have isolated numerous mutants containing mutations in the salvage pathways of purine synthesis. The mutations cause deficiencies in adenine phosphoribosyltransferase (adeF), in hypoxanthine-guanine phosphoribosyltransferase (guaF), in adenine deaminase (adeC), in inosine-guanosine phosphorylase, (guaP), and in GMP reductase (guaC). The physiological properties of mutants containing one or more of these mutations and corresponding enzyme measurements have been used to derive a metabolic chart of the purine salvage pathway of Bacillus subtilis.
摘要
我们已经分离出许多在嘌呤合成补救途径中发生突变的突变体。这些突变导致腺嘌呤磷酸核糖转移酶（adeF）、次黄嘌呤 - 鸟嘌呤磷酸核糖转移酶（guaF）、腺嘌呤脱氨酶（adeC）、肌苷 - 鸟苷磷酸化酶（guaP）和GMP还原酶（guaC）出现缺陷。含有这些突变中的一种或多种的突变体的生理特性以及相应的酶活性测定已被用于绘制枯草芽孢杆菌嘌呤补救途径的代谢图。
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