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1
Genetic separation of hypoxanthine and guanine-xanthine phosphoribosyltransferase activities by deletion mutations in Salmonella typhimurium.通过鼠伤寒沙门氏菌中的缺失突变对次黄嘌呤和鸟嘌呤-黄嘌呤磷酸核糖基转移酶活性进行遗传分离。
J Bacteriol. 1972 Nov;112(2):910-6. doi: 10.1128/jb.112.2.910-916.1972.
2
Genetic modification of substrate specificity of hypoxanthine phosphoribosyltransferase in Salmonella typhimurium.鼠伤寒沙门氏菌中次黄嘌呤磷酸核糖基转移酶底物特异性的基因改造。
J Bacteriol. 1975 Jan;121(1):77-82. doi: 10.1128/jb.121.1.77-82.1975.
3
Purine phosphoribosyltransferases of Salmonella typhimurium.鼠伤寒沙门氏菌的嘌呤磷酸核糖转移酶
J Bacteriol. 1972 Nov;112(2):1010-3. doi: 10.1128/jb.112.2.1010-1013.1972.
4
Genetic separation of purine transport from phosphoribosyltransferase activity in Salmonella typhimurium.鼠伤寒沙门氏菌中嘌呤转运与磷酸核糖基转移酶活性的遗传分离。
J Gen Microbiol. 1980 Dec;121(2):357-64. doi: 10.1099/00221287-121-2-357.
5
Defective guanine uptake in an 8-azaguanine-resistant mutant of Salmonella typhimurium.鼠伤寒沙门氏菌8-氮杂鸟嘌呤抗性突变体中鸟嘌呤摄取缺陷。
J Bacteriol. 1968 Feb;95(2):458-64. doi: 10.1128/jb.95.2.458-464.1968.
6
The substrate specificity of purine phosphoribosyltransferases in Schizosaccharomyces pombe.粟酒裂殖酵母中嘌呤磷酸核糖转移酶的底物特异性。
Biochem J. 1971 May;122(4):415-20. doi: 10.1042/bj1220415.
7
Purine metabolism in Neisseria meningitidis. 3. Utilization of exogenous hypoxanthine, guanine and xanthine.脑膜炎奈瑟菌中的嘌呤代谢。3. 外源性次黄嘌呤、鸟嘌呤和黄嘌呤的利用
Acta Pathol Microbiol Scand B. 1975 Oct;83(5):397-406.
8
Alteration of repression in purine biosynthesis.
Biochim Biophys Acta. 1967 Apr 18;138(2):221-9. doi: 10.1016/0005-2787(67)90483-2.
9
Escherichia coli mutants deficient in guanine-xanthine phosphoribosyltransferase.缺乏鸟嘌呤-黄嘌呤磷酸核糖基转移酶的大肠杆菌突变体。
J Bacteriol. 1976 Jun;126(3):1141-8. doi: 10.1128/jb.126.3.1141-1148.1976.
10
Regulation of purine utilization in bacteria. VI. Characterization of hypoxanthine and guanine uptake into isolated membrane vesicles from Salmonella typhimurium.细菌中嘌呤利用的调控。VI. 鼠伤寒沙门氏菌分离的膜泡对次黄嘌呤和鸟嘌呤摄取的特性
J Bacteriol. 1976 Apr;126(1):312-26. doi: 10.1128/jb.126.1.312-326.1976.

引用本文的文献

1
Linkage map of Escherichia coli K-12, edition 10: the traditional map.大肠杆菌K-12连锁图谱，第10版：传统图谱。
Microbiol Mol Biol Rev. 1998 Sep;62(3):814-984. doi: 10.1128/MMBR.62.3.814-984.1998.
2
Characterization of guanine and hypoxanthine phosphoribosyltransferases in Methanococcus voltae.沃氏甲烷球菌中鸟嘌呤和次黄嘌呤磷酸核糖基转移酶的特性分析。
J Bacteriol. 1996 May;178(9):2521-6. doi: 10.1128/jb.178.9.2521-2526.1996.
3
Isolation and characterization of purine regulatory mutants of Salmonella typhimurium with an episomal purE-lac fusion.利用附加体质粒purE-lac融合对鼠伤寒沙门氏菌嘌呤调节突变体进行分离和鉴定。
J Bacteriol. 1982 Jul;151(1):153-61. doi: 10.1128/jb.151.1.153-161.1982.
4
Mechanism of adenine toxicity in Escherichia coli.大肠杆菌中腺嘌呤毒性的机制。
J Bacteriol. 1982 Mar;149(3):923-30. doi: 10.1128/jb.149.3.923-930.1982.
5
Molecular cloning of genes involved in purine biosynthetic and salvage pathways of Salmonella typhimurium.鼠伤寒沙门氏菌嘌呤生物合成及补救途径相关基因的分子克隆
Mol Gen Genet. 1984;196(1):152-7. doi: 10.1007/BF00334108.
6
Purine salvage pathways of Bacillus subtilis and effect of guanine on growth of GMP reductase mutants.枯草芽孢杆菌的嘌呤补救途径及鸟嘌呤对GMP还原酶突变体生长的影响。
J Bacteriol. 1983 Jul;155(1):169-79. doi: 10.1128/jb.155.1.169-179.1983.
7
Hypoxanthine: guanine phosphoribosyltransferase mutants in Saccharomyces cerevisiae.酿酒酵母中的次黄嘌呤：鸟嘌呤磷酸核糖转移酶突变体
Mol Gen Genet. 1983;191(3):407-12. doi: 10.1007/BF00425755.
8
Guanine uptake and metabolism in Neurospora crassa.粗糙脉孢菌中鸟嘌呤的摄取与代谢
J Bacteriol. 1982 Mar;149(3):941-7. doi: 10.1128/jb.149.3.941-947.1982.
9
Evolution of a new gene substituting for the leuD gene of Salmonella typhimurium: origin and nature of supQ and newD mutations.鼠伤寒沙门氏菌亮氨酸脱氢酶基因替代新基因的进化：supQ和newD突变的起源与性质
J Bacteriol. 1974 Dec;120(3):1176-85. doi: 10.1128/jb.120.3.1176-1185.1974.
10
Use of Escherichia coli mutants to evaluate purines, purine nucleosides, and analogues.利用大肠杆菌突变体评估嘌呤、嘌呤核苷及类似物。
Antimicrob Agents Chemother. 1973 Aug;4(2):125-32. doi: 10.1128/AAC.4.2.125.

本文引用的文献

1
Metabolism of 6-Mercaptopurine by Resistant Escherichia coli Cells.耐药性大肠杆菌细胞对6-巯基嘌呤的代谢
J Bacteriol. 1966 Aug;92(2):446-54. doi: 10.1128/jb.92.2.446-454.1966.
2
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
3
Alterations in purine nucleotide pyrophosphorylases and resistance to purine analogues.嘌呤核苷酸焦磷酸化酶的改变与对嘌呤类似物的抗性
Biochim Biophys Acta. 1961 Oct 14;53:166-73. doi: 10.1016/0006-3002(61)90803-4.
4
Purine nucleotide cycles and their metabolic role.嘌呤核苷酸循环及其代谢作用。
J Biol Chem. 1960 Sep;235:2672-81.
5
GENETIC ALTERATION OF ADENYLIC PYROPHOSPHORYLASE IN SALMONELLA.沙门氏菌中腺苷酸焦磷酸化酶的基因改变
Science. 1963 Nov 8;142(3593):680-1. doi: 10.1126/science.142.3593.680.
6
Reaction of 6-mercaptopurine with inosine- and guanosine-5'-phosphate pyrophosphorylase purified from E. coli.
Biochem Pharmacol. 1959 Aug;2:105-11. doi: 10.1016/0006-2952(59)90077-2.
7
Mechanism of resistance to 2,6-diaminopurine in Salmonella typhimurium.鼠伤寒沙门氏菌对2,6-二氨基嘌呤的耐药机制。
Biochim Biophys Acta. 1961 Jul 22;51:130-7. doi: 10.1016/0006-3002(61)91023-x.
8
Acetylornithinase of Escherichia coli: partial purification and some properties.大肠杆菌的乙酰鸟氨酸酶：部分纯化及某些性质
J Biol Chem. 1956 Jan;218(1):97-106.
9
Xanthine phosphoribosyltransferase in man: relationship to hypoxanthine-guanine phosphoribosyltransferase.人类中的黄嘌呤磷酸核糖基转移酶：与次黄嘌呤 - 鸟嘌呤磷酸核糖基转移酶的关系。
Biochem Biophys Res Commun. 1967 Aug 7;28(3):340-5. doi: 10.1016/0006-291x(67)90315-4.
10
Human hypoxanthine phosphoribosyltransferase. I. Purification, properties, and specificity.人次黄嘌呤磷酸核糖基转移酶。I. 纯化、性质及特异性
J Biol Chem. 1969 Mar 10;244(5):1263-70.

通过鼠伤寒沙门氏菌中的缺失突变对次黄嘌呤和鸟嘌呤-黄嘌呤磷酸核糖基转移酶活性进行遗传分离。

Genetic separation of hypoxanthine and guanine-xanthine phosphoribosyltransferase activities by deletion mutations in Salmonella typhimurium.

作者信息

Gots J S, Benson C E, Shumas S R

出版信息

J Bacteriol. 1972 Nov;112(2):910-6. doi: 10.1128/jb.112.2.910-916.1972.

DOI:10.1128/jb.112.2.910-916.1972
PMID:4563984
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC251503/
Abstract

Certain proAB deletion mutants of Salmonella typhimurium were found to be simultaneously deleted in a gene required for the utilization of guanine and xanthine (designated gxu). These mutants were resistant to 8-azaguanine and when carrying an additional pur mutation were unable to use guanine or xanthine as a purine source. The defect was correlated with deficiencies in the uptake and phosphoribosyltransferase activities for guanine and xanthine. Hypoxanthine and adenine activities were unaltered. The deficiency was restored to normal by transduction to pro(+) and in F' merodiploids.

摘要

鼠伤寒沙门氏菌的某些proAB缺失突变体被发现同时缺失了利用鸟嘌呤和黄嘌呤所需的一个基因（命名为gxu）。这些突变体对8-氮杂鸟嘌呤具有抗性，并且当携带额外的嘌呤突变时，无法将鸟嘌呤或黄嘌呤用作嘌呤来源。该缺陷与鸟嘌呤和黄嘌呤的摄取及磷酸核糖基转移酶活性的缺陷相关。次黄嘌呤和腺嘌呤的活性未改变。通过转导至pro(+)以及在F'部分二倍体中，该缺陷恢复正常。