非甾体抗炎药对大豆脂氧合酶的抑制作用。
Soybean lipoxygenase inhibition by nonsteroidal antiinflammatory drugs.
作者信息
Sircar J C, Schwender C F, Johnson E A
出版信息
Prostaglandins. 1983 Mar;25(3):393-6. doi: 10.1016/0090-6980(83)90042-4.
PMID:6408711
Abstract
Eighteen known nonsteroidal antiinflammatory drugs (NSAID) were tested for their action against soybean lipoxygenase (E.C.1.13.11.12) using linoleic acid as substrate. It was found that the best inhibitors of lipoxygenase were naproxen, BW 755C, indomethacin and isoxicam. Drugs with intermediate potency were meclofenamic acid, phenylbutazone and benoxaprofen. Other drugs such as ibuprofen and zomepirac were only weakly active in the test.
摘要
以亚油酸为底物，对18种已知的非甾体抗炎药（NSAID）进行了抗大豆脂氧合酶（E.C.1.13.11.12）活性测试。结果发现，脂氧合酶的最佳抑制剂是萘普生、BW 755C、吲哚美辛和异恶酰胺。中等活性的药物有甲氯芬那酸、保泰松和苯恶洛芬。其他药物如布洛芬和佐美酸在该测试中活性较弱。
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