异恶酰氨基比林及其他非甾体抗炎药对大鼠腹膜白细胞花生四烯酸代谢的影响。

Effects of isoxicam and other non-steroidal anti-inflammatory drugs on arachidonic acid metabolism by rat peritoneal leucocytes.

作者信息

Tavares I A, Capasso F, Vine N D, Bennett A

出版信息

J Pharm Pharmacol. 1985 Aug;37(8):587-8. doi: 10.1111/j.2042-7158.1985.tb03077.x.

DOI:10.1111/j.2042-7158.1985.tb03077.x

Abstract

Inhibition of prostaglandin formation from [14C]arachidonic acid by rat peritoneal leucocytes occurred with nonsteroidal anti-inflammatory drugs, their order of potency being indomethacin greater than piroxicam greater than naproxen greater than ibuprofen greater than isoxicam. At the lowest concentration tested (1 microgram ml-1), indomethacin markedly increased the accumulation of lipoxygenase products in the cell incubates. Naproxen, ibuprofen or piroxicam 1 or 10 micrograms ml-1 resulted in smaller increases of lipoxygenase products, and there was only a small rise with these concentrations of isoxicam.

摘要

大鼠腹膜白细胞对[14C]花生四烯酸生成前列腺素的抑制作用在使用非甾体抗炎药时出现，其效力顺序为吲哚美辛大于吡罗昔康大于萘普生大于布洛芬大于异恶草酮。在测试的最低浓度（1微克/毫升）下，吲哚美辛显著增加了细胞培养液中脂氧合酶产物的积累。萘普生、布洛芬或1或10微克/毫升的吡罗昔康导致脂氧合酶产物的增加较小，而这些浓度的异恶草酮仅引起小幅上升。