Troll U, Grossner D, Schröpfer S
Anasth Intensivther Notfallmed. 1983 Apr;18(2):71-8.
16 patients with major abdominal surgery were treated 3 days preoperatively and 5 days postoperatively with a new parenteral nutrition solution containing amino acids, dextrose, sugar substitutes and electrolytes. The efficacy of the solution was tested with respect to various clinical data including amino acid homoeostasis and nitrogen balance. Even in the postoperative period free serum amino acids remained generally within the normal range. Nitrogen balance was slightly negative. With the exception of the 1st postoperative day glucose concentrations were in the upper normal range. The renal losses were about 1% for glucose and 7% for the sugar substitutes. Serum electrolyte concentrations were normal during the investigation period. Because of the high substrate concentration in the solution it was possible to administer 70 g of amino acids and 420 g of non-protein energy sources in an infusion volume of only 2000 ml.
16例接受腹部大手术的患者在术前3天和术后5天接受一种新的肠外营养溶液治疗,该溶液含有氨基酸、葡萄糖、代糖和电解质。针对包括氨基酸稳态和氮平衡在内的各种临床数据对该溶液的疗效进行了测试。即使在术后阶段,游离血清氨基酸总体上仍保持在正常范围内。氮平衡略呈负值。除术后第1天外,血糖浓度均处于正常范围上限。葡萄糖的肾丢失量约为1%,代糖的肾丢失量约为7%。在研究期间,血清电解质浓度正常。由于该溶液中底物浓度高,仅用2000毫升的输注量就可以给予70克氨基酸和420克非蛋白质能量来源。