Lescaudron L, Verna A
Exp Brain Res. 1985;58(2):362-7. doi: 10.1007/BF00235317.
The effects of a 9-month period of ethanol consumption (followed by 3 or 6 months of withdrawal) on the hippocampus of mice were investigated. Compared with control animals, a loss of hippocampal neurons was observed on histological sections from ethanol-treated mice. This loss was greater in the ventral hippocampus (-18.6% to -18.7%) than in the dorsal hippocampus (-5.2% to -8.5%). However, the nucleus diameter, as well as the number of dendritic spines (studied using the Golgi-rapid impregnation) of the remaining neurons was not significantly affected by chronic ethanol consumption in our experimental conditions.
研究了9个月乙醇摄入期（随后3或6个月戒断）对小鼠海马体的影响。与对照动物相比，在乙醇处理小鼠的组织学切片上观察到海马神经元丢失。腹侧海马体的这种丢失（-18.6%至-18.7%）比背侧海马体（-5.2%至-8.5%）更严重。然而，在我们的实验条件下，剩余神经元的细胞核直径以及树突棘数量（使用高尔基快速浸染法研究）并未受到慢性乙醇摄入的显著影响。
