[评估脑膜炎球菌携带状态的流行病学和实验室标准]

[Epidemiological and laboratory criteria in the assessment of meningococcus carrier state].

作者信息

Demina A A, Pokrovskiĭ V I, Kuz'menko S V, Deviatkina N P, Larina L I

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1976 Oct(10):79-85.

Abstract

A study was made of the duration of meningococcus carrier state, immunological indices and group-specific properties of meningococci isolated from them. The periods of meningococcus discharge were studied in 738 persons. Three categories of the carrier state were revealed: a single discharge (67% of the carriers), of average duration (up to 4 weeks), and prolonged. Greater indices of group-specific antibodies (in the passive hemagglutination test) were revealed in the carriers with prolonged presence of meningococci in the nasopharynx. Dynamics of immunological indices and periods of the carrier state formation in the foci of infection permitted to characterize the prolonged carrier state as a latent form of meningococcus infection. A study of the group-specific properties in 1845 strains and comparison of the group-specific pattern of the circulating strains with the epidemic situation indicated that meningococci of group A were not only epidemic, but also more virulent.

摘要

对脑膜炎球菌携带状态的持续时间、免疫指标以及从携带者中分离出的脑膜炎球菌的群特异性特性进行了研究。对738人进行了脑膜炎球菌排出期的研究。发现了三类携带状态：单次排出（占携带者的67%），平均持续时间（长达4周），以及持续时间延长。在鼻咽部长期存在脑膜炎球菌的携带者中，发现了更高的群特异性抗体指标（在被动血凝试验中）。感染灶中免疫指标的动态变化和携带状态形成期表明，持续时间延长的携带状态可被视为脑膜炎球菌感染的一种潜伏形式。对1845株菌株的群特异性特性进行研究，并将流行菌株的群特异性模式与疫情情况进行比较，结果表明，A群脑膜炎球菌不仅具有流行性，而且毒性更强。