Paul T, Flatz G
Enzyme. 1983;30(1):54-8. doi: 10.1159/000469545.
The present study was performed in order to clarify controversies concerning the effect of thyroxine on lactase activity in young mammals. Lactase activity was determined in suckling rats with two reference systems (protein and DNA) after one and three thyroxine injections (0.2 mg/100 g body weight). In comparison with control animals lactase activity was decreased after thyroxine administration. The thyroxine effect was dosage-dependent: three injections caused a more profound and prolonged depression of lactase activity. In both thyroxine-treated groups lactase activity returned to age-specific normal levels before the low lactase activity of adult rats was attained. The transient thyroxine-induced changes of lactase activity were similar to the reference parameters protein and DNA.
本研究旨在澄清有关甲状腺素对幼年哺乳动物乳糖酶活性影响的争议。在给乳鼠注射两次甲状腺素（0.2mg/100g体重）后，用两种参照体系（蛋白质和DNA）测定乳糖酶活性。与对照动物相比，给予甲状腺素后乳糖酶活性降低。甲状腺素的作用呈剂量依赖性：注射三次导致乳糖酶活性更显著且持久的降低。在两个甲状腺素处理组中，乳糖酶活性在达到成年大鼠低乳糖酶活性之前均恢复到特定年龄的正常水平。甲状腺素诱导的乳糖酶活性的短暂变化与参照参数蛋白质和DNA相似。
