Borkenstein M H
Eur J Pediatr. 1983 Mar;140(1):17-8. doi: 10.1007/BF00661897.
The effects of intranasally applied TRH on serum TSH and PRL were investigated in ten healthy, prepubertal children. Serum levels of T4, T3, TSH, and PRL were all in the normal range. Synthetic TRH, 500 micrograms, in water was insufflated in one nostril. Intranasal TRH induced a prompt rise of TSH and PRL in all children with peak values at 30 min. TSH: 10.29 +/- 1.24 microU/ml; PRL: 25.12 +/- 3.53 ng/ml (mean +/- SEM). TSH values were still significant raised 120 min after the insufflation (P less than 0.025) whereas the PRL values did not differ significantly. A dose-dependent TSH release following intranasal sprayed TRH was shown. delta TSH and TSH values at 120 min were significantly higher in children receiving greater than 10 micrograms/kg TRH than in children receiving less than 10 micrograms/kg (P less than 0.025; P less than 0.05). Dose dependent differences in PRL release following intranasal TRH were not shown. Any side effects of intranasally applied TRH were not observed. Intranasal insufflation of synthetic TRH seems to be a valuable and harmless tool for the evaluation of pituitary TSH and PRL secretory reserve.
在10名健康的青春期前儿童中研究了经鼻应用促甲状腺激素释放激素（TRH）对血清促甲状腺激素（TSH）和催乳素（PRL）的影响。血清甲状腺素（T4）、三碘甲状腺原氨酸（T3）、TSH和PRL水平均在正常范围内。将500微克合成TRH溶于水中，经一个鼻孔喷入。经鼻给予TRH后，所有儿童的TSH和PRL迅速升高，在30分钟时达到峰值。TSH：10.29±1.24微单位/毫升；PRL：25.12±3.53纳克/毫升（平均值±标准误）。喷入后120分钟时TSH值仍显著升高（P<0.025），而PRL值无显著差异。结果显示经鼻喷洒TRH后TSH呈剂量依赖性释放。接受TRH大于10微克/千克的儿童在120分钟时的TSH变化值（ΔTSH）和TSH值显著高于接受TRH小于10微克/千克的儿童（P<0.025；P<0.05）。未显示经鼻给予TRH后PRL释放的剂量依赖性差异。未观察到经鼻应用TRH的任何副作用。经鼻喷入合成TRH似乎是评估垂体TSH和PRL分泌储备的一种有价值且无害的方法。
