日本原发性胆汁性肝硬化和自身免疫性肝炎患者的人类白细胞抗原（HLA）抗原
HLA antigens in Japanese patients with primary biliary cirrhosis and autoimmune hepatitis.
作者信息
Miyamori H, Kato Y, Kobayashi K, Hattori N
出版信息
Digestion. 1983;26(4):213-7. doi: 10.1159/000198892.
22 Japanese patients with primary biliary cirrhosis and 12 patients with autoimmune hepatitis were studied for HLA antigens. In the patients with primary biliary cirrhosis, HLA-DR2 showed a statistically higher frequency compared to the controls (68 versus 30%, chi 2 corr. = 7.660, p less than 0.007, p corr. less than 0.042, RR = 5.00). In the patients with autoimmune hepatitis, HLA-A10 showed a somewhat higher frequency compared to the controls (50 versus 19%, chi 2 corr. = 4.824, p less than 0.05, p corr. NS, RR = 4.36). In the DR locus, DR2 and DR4 showed tendencies toward increased frequency, but these were not statistically significant.
对22例原发性胆汁性肝硬化日本患者和12例自身免疫性肝炎患者进行了HLA抗原研究。在原发性胆汁性肝硬化患者中，与对照组相比，HLA - DR2的出现频率在统计学上更高（68%对30%，校正卡方值=7.660，p<0.007，校正p<0.042，相对危险度=5.00）。在自身免疫性肝炎患者中，与对照组相比，HLA - A10的出现频率略高（50%对19%，校正卡方值=4.824，p<0.05，校正p无统计学意义，相对危险度=4.36）。在DR基因座中，DR2和DR4有出现频率增加的趋势，但无统计学意义。
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