Hu F, Mah K, Teramura D J
Cancer Res. 1982 Jul;42(7):2786-91.
The effects of theophylline and melanocyte-stimulating hormone on B16 melanoma cells in culture cells were studied by electron microscopy and dopa cytochemistry. The data show that theophylline and melanocyte-stimulating hormone enhance melanogenesis by activating tyrosinase synthesis and its transfer but that neither affects the synthesis of the well-organized eumelanosome matrix. Their pigmenting effects appear to be limited to the melanogenic cells and result from a marked increase, particularly in theophylline-treated cells, in pheomelanosome formation.
通过电子显微镜和多巴细胞化学研究了茶碱和促黑素细胞激素对培养细胞中B16黑色素瘤细胞的影响。数据表明，茶碱和促黑素细胞激素通过激活酪氨酸酶的合成及其转移来增强黑色素生成，但两者均不影响结构良好的真黑素小体基质的合成。它们的色素沉着作用似乎仅限于黑素生成细胞，并且特别是在茶碱处理的细胞中，是由于褐黑素小体形成的显著增加所致。
