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干扰素对小鼠细胞色素P-450的影响：部分纯化的抗原特异性干扰素-γ的作用

Effect of interferon on murine cytochrome P-450: effect of partially purified antigen-specific interferon-gamma.

作者信息

Smith P K, Nerland D E, Sonnenfeld G

出版信息

J Interferon Res. 1983;3(2):219-22. doi: 10.1089/jir.1983.3.219.

DOI:10.1089/jir.1983.3.219
PMID:6409972
Abstract

Gamma interferon (IFN-gamma), induced by sensitization of mice with Mycobacterium bovis strain BCG followed by challenge with tuberculin, was partially purified by adsorption on silicic acid. Administration of the partially purified IFN-gamma to mice significantly depressed levels of liver microsomal cytochrome P-450 to an equivalent extent as crude IFN-gamma.

摘要

γ干扰素（IFN-γ）由牛分枝杆菌卡介苗菌株致敏小鼠后再用结核菌素攻击诱导产生，通过吸附在硅酸上进行部分纯化。将部分纯化的IFN-γ给予小鼠后，肝脏微粒体细胞色素P-450水平显著降低，降低程度与粗制IFN-γ相当。

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