II型干扰素的诱导和被动转移会抑制小鼠细胞色素P-450药物代谢系统。
Type II interferon induction and passive transfer depress the murine cytochrome P-450 drug metabolism system.
作者信息
Sonnenfeld G, Harned C L, Thaniyavarn S, Huff T, Mandel A D, Nerland D E
出版信息
Antimicrob Agents Chemother. 1980 Jun;17(6):969-72. doi: 10.1128/AAC.17.6.969.
Induction of type II interferon by sensitization of mice with Mycobacterium tuberculosis strain BCG and challenge with tuberculin resulted in a depression of the cytochrome P-450 drug metabolism system of the liver. The degree of depression was significantly greater than in mice that were only sensitized to BCG. Cytochrome b5 levels were not affected. In addition, the level of the depression of the cytochrome P-450 system correlated with the levels of type II interferon induced. Passive transfer of exogenous type II interferon preparations also significantly depressed the cytochrome P-450 system. Passive transfer of mock interferon or of normal serum had no effect.
用卡介苗结核杆菌菌株对小鼠进行致敏并注射结核菌素后诱导产生II型干扰素，导致肝脏细胞色素P - 450药物代谢系统受到抑制。这种抑制程度明显大于仅对卡介苗致敏的小鼠。细胞色素b5水平未受影响。此外，细胞色素P - 450系统的抑制程度与诱导产生的II型干扰素水平相关。外源性II型干扰素制剂的被动转移也显著抑制了细胞色素P - 450系统。模拟干扰素或正常血清的被动转移则没有效果。
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