变异型和原始L细胞中干扰素诱导的低反应状态：细胞分裂的必要条件。
The interferon-induced hyporesponsive state in variant and parental L cells: a requirement for cell division.
作者信息
Veomett G E, Lahm B D, Hawkins J
出版信息
J Gen Virol. 1983 Aug;64 (Pt 8):1735-41. doi: 10.1099/0022-1317-64-8-1735.
PMID:6409991
Abstract
L cells grown for 18 to 22 months in the presence of interferon (IFN) retained their sensitivity to the antiviral effect of IFN but were less sensitive to cell growth inhibition by IFN. Moreover, the parental and variant lines became hyporesponsive (i.e. less responsive to virus induction of IFN) with different kinetics after IFN treatment. Experiments using mitomycin C to inhibit cell division suggested that cell division is required to enter the hyporesponsive state.
摘要
在干扰素（IFN）存在的情况下培养18至22个月的L细胞保留了对IFN抗病毒作用的敏感性，但对IFN抑制细胞生长的作用不太敏感。此外，亲代细胞系和变异细胞系在IFN处理后，以不同的动力学变得反应低下（即对病毒诱导IFN的反应性降低）。使用丝裂霉素C抑制细胞分裂的实验表明，进入反应低下状态需要细胞分裂。
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