Zhuang H, Coulepis A G, Locarnini S A, Kaldor J, Marshall J A, Gust I D
J Med Virol. 1983;11(4):267-76. doi: 10.1002/jmv.1890110402.
During a search for the aetiological agent of non-A non-B hepatitis, a precipitating antigen was detected in the sera of some patients during the acute phase of their illness. The antigen was detected by agar gel diffusion using antibody from convalescent sera obtained from patients with non-A non-B hepatitis, and from haemophiliac sera. The antigen was usually detected early in the patient's illness, disappearing as liver function tests returned to normal. In some patients specific antibody appeared during the convalescent phase of the disease. The antigen does not appear to be specific for non-A non-B hepatitis, as it could be detected with similar frequency in patients with hepatitis A or hepatitis B and some patients with other liver disorders. Biochemical and biophysical studies suggest that the antigen is probably an abnormal lipoprotein produced as a result of acute liver damage.
在寻找非甲非乙型肝炎的病原体过程中，在一些患者疾病急性期的血清中检测到一种沉淀抗原。使用从非甲非乙型肝炎患者康复期血清以及血友病患者血清中获得的抗体，通过琼脂凝胶扩散法检测到了该抗原。该抗原通常在患者患病早期被检测到，随着肝功能检查恢复正常而消失。在一些患者中，特异性抗体在疾病康复期出现。该抗原似乎并非非甲非乙型肝炎所特有，因为在甲型肝炎、乙型肝炎患者以及一些患有其他肝脏疾病的患者中也能以相似的频率检测到。生化和生物物理研究表明，该抗原可能是急性肝损伤产生的一种异常脂蛋白。
