De novo development of hypercholesterolaemia and increased HDL-cholesterol: apoprotein A-I ratio in patients with chronic renal failure following kidney transplantation.

Lipid profiles were studied in 27 kidney transplant patients with stable renal function during long term follow-up and 18 haemodialysis patients. Hypertriglyceridaemia resolved after kidney transplantation. In contrast, hypercholesterolaemia developed and persisted in transplant patients. HDL-CHL temporarily elevated at 1-5 years post-transplant compared to decreased values during haemodialysis. HDL-CHL:Apo . A-I ratio became elevated post-transplant, although no variation in Apo . A-I values was observed between either groups. It is suggested that qualitative and quantitative changes of HDL particles develop after grafting.