Pomara N, Block R, Demetriou S, Fucek F, Stanley M, Gershon S
Psychopharmacology (Berl). 1983;80(2):129-30. doi: 10.1007/BF00427955.
Chronic treatment of rats with choline caused a decrease in the hypothermic response to pilocarpine. The action of choline on the muscarinic receptors is consistent with electrophysiological and binding studies, supporting a direct muscarinic action for choline. Administration of direct muscarinic agonists has been shown to cause a decrease in the number of muscarinic receptors. Thus, the long-term use of cholinergic precursors could have some adverse effects on central cholinergic functioning.
用胆碱对大鼠进行长期治疗会导致对毛果芸香碱的体温过低反应降低。胆碱对毒蕈碱受体的作用与电生理和结合研究结果一致，支持胆碱具有直接的毒蕈碱样作用。已表明给予直接的毒蕈碱激动剂会导致毒蕈碱受体数量减少。因此，长期使用胆碱能前体可能会对中枢胆碱能功能产生一些不利影响。
