Ulus I H, Wurtman R J
Science. 1976 Dec 3;194(4269):1060-1. doi: 10.1126/science.10629.
The administration of choline in doses previously shown to elevate brain acetylcholine concentrations also increases the activity of tyrosine hydroxylase in rat caudate nuclei. This response can be blocked by atropine, a muscarinic antagonist. These findings indicate that choline-induced increases in acetylcholine concentrations may be associated with parallel changes in the amount of the neurotransmitter released into synapses.
给予先前已证明能提高脑内乙酰胆碱浓度的剂量的胆碱，也会增加大鼠尾状核中酪氨酸羟化酶的活性。这种反应可被毒蕈碱拮抗剂阿托品阻断。这些发现表明，胆碱诱导的乙酰胆碱浓度升高可能与释放到突触中的神经递质数量的平行变化有关。
