Young R, Rosecrans J A, Glennon R A
Psychopharmacology (Berl). 1983;80(2):156-60. doi: 10.1007/BF00427960.
The discriminative effects of 5-methoxy-N,N-dimethyltryptamine (5-OMeDMT) were studied in rats trained to discriminate 1.5 mg/kg or 3.0 mg/kg 5-OMeDMT from saline. A series of antagonist and generalization tests revealed that (1) antagonism of the 5-OMeDMT stimulus response by the presumed serotonin antagonist BC-105 depended on the dose of 5-OMeDMT, (2) the 5-OMeDMT stimulus generalized to LSD, and (3) like 5-OMeDMT, antagonism of the LSD generalization response by BC-105 depended on the dose of LSD. In a second study, with rats responding under a variable-interval (VI) 15-s schedule of reinforcement, doses of 1.0-3.0 mg/kg 5-OMeDMT significantly decreased response rate. Furthermore, the decrease in responding produced by the administration of 1.5 mg/kg (but not by 3.0 mg/kg) 5-OMeDMT was blocked by BC-105. This dose-dependent antagonism was of particular interest since the 1.5 mg/kg and 3.0 mg/kg dose of 5-O-MeDMT had essentially the same effect on responding when given alone. The results of both studies emphasize the importance of 5-OMeDMT dose in antagonism experiments.
在训练大鼠区分1.5毫克/千克或3.0毫克/千克5-甲氧基-N,N-二甲基色胺（5-OMeDMT）与生理盐水的实验中，研究了5-OMeDMT的辨别效应。一系列拮抗剂和泛化测试表明：（1）假定的5-羟色胺拮抗剂BC-105对5-OMeDMT刺激反应的拮抗作用取决于5-OMeDMT的剂量；（2）5-OMeDMT刺激可泛化至麦角酸二乙酰胺（LSD）；（3）与5-OMeDMT一样，BC-105对LSD泛化反应的拮抗作用也取决于LSD的剂量。在第二项研究中，大鼠在可变间隔（VI）15秒强化程序下做出反应，1.0 - 3.0毫克/千克剂量的5-OMeDMT显著降低了反应率。此外，1.5毫克/千克（而非3.0毫克/千克）剂量的5-OMeDMT给药所导致的反应减少被BC-105阻断。这种剂量依赖性拮抗作用尤为引人关注，因为单独给予1.5毫克/千克和3.0毫克/千克剂量的5-OMeDMT对反应的影响基本相同。两项研究结果均强调了5-OMeDMT剂量在拮抗实验中的重要性。
