Arem R, Zoghbi W, Chan L
Surg Neurol. 1983 Aug;20(2):109-12. doi: 10.1016/0090-3019(83)90459-7.
A 40-year-old woman had a 1-year history of amenorrhea-galactorrhea. She was found to have an intrasellar tumor with suprasellar extension and a prolactin level of 98.1 ng/mL. Subtotal resection of the tumor resulted in a return of the prolactin level to normal within 4 days of the operation and of the prolactin response to thyrotropin releasing hormone, accompanied by the disappearance of the galactorrhea. Histologic examination revealed a typical craniopharyngioma. These observations indicate that one important mechanism of hyperprolactinemia in patients with craniopharyngioma is direct encroachment on the hypothalamus and/or pituitary stalk by the tumor and interruption of prolactin inhibiting factor.
一名40岁女性有1年闭经-溢乳病史。她被发现患有鞍内肿瘤并向鞍上扩展，催乳素水平为98.1 ng/mL。肿瘤次全切除术后，催乳素水平在术后4天内恢复正常，对促甲状腺激素释放激素的催乳素反应也恢复正常，同时溢乳消失。组织学检查显示为典型的颅咽管瘤。这些观察结果表明，颅咽管瘤患者高催乳素血症的一个重要机制是肿瘤直接侵犯下丘脑和/或垂体柄，导致催乳素抑制因子中断。
