Shah R P, Leavens M E, Samaan N A
Arch Intern Med. 1980 Dec;140(12):1608-12.
We describe two women with amenorrhea, galactorrhea, and cranial nerve palsy. Elevated serum prolactin levels were found in both patients before and after administration of protirelin. Both patients had an abnormal sella turcica with suprasellar mass. A prolactin-secreting tumor with suprasellar extension was considered, but further investigation and surgical exploration showed that both patients had parasellar meningiomas. These findings indicate that parasellar meningioma can produce hypothalamic-pituitary dysfunction and should be considered in the differential diagnosis of women with galactorrhea and amenorrhea.
我们描述了两名患有闭经、溢乳和颅神经麻痹的女性。两名患者在注射促甲状腺素释放激素前后血清催乳素水平均升高。两名患者均有蝶鞍异常伴鞍上肿块。考虑为分泌催乳素的肿瘤伴鞍上扩展，但进一步检查和手术探查显示两名患者均患有鞍旁脑膜瘤。这些发现表明，鞍旁脑膜瘤可导致下丘脑 - 垂体功能障碍，在伴有溢乳和闭经的女性鉴别诊断中应予以考虑。
