文献检索，用中文搜 PubMed

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Jones A R, Mashford P M

Xenobiotica. 1983 Feb;13(2):73-9. doi: 10.3109/00498258309052239.

The fate of N-methyl-N'-(hydroxy[14C]methyl)thiourea (MHT) has been studied in the male Sprague-Dawley rat. The compound is degraded to N-methylthiourea and formaldehyde. 2. N-Methylthiourea is excreted as a urinary metabolite whereas the formaldehyde is not excreted, either in the urine or the expired air, but is metabolized via formate to CO2. 3. At least 50% of an i.p. dose (100 mg/kg) of MHT is excreted unchanged and some of this undergoes hydrolysis within the urine to N-methylthiourea and formaldehyde. Production of formaldehyde leads to the formation of the urinary artefact N-(hydroxymethyl)urea. 4. Tissue-distribution studies with 14C-MHT have shown that radioactivity is selectively associated with the thyroid gland. A preliminary investigation has indicated that MHT has anti-thyroid hormone activity as it lowers the thyroxine in rat serum.

已在雄性斯普拉格 - 道利大鼠中研究了N - 甲基 - N' -（羟基[¹⁴C]甲基）硫脲（MHT）的代谢情况。该化合物降解为N - 甲基硫脲和甲醛。2. N - 甲基硫脲作为尿液代谢产物排出，而甲醛既不通过尿液也不通过呼出气体排出，而是通过甲酸代谢为二氧化碳。3. 腹腔注射剂量为100 mg/kg的MHT中，至少50%以原形排出，其中一些在尿液中水解为N - 甲基硫脲和甲醛。甲醛的产生导致尿液中出现人为产物N -（羟甲基）脲。4. 用¹⁴C - MHT进行的组织分布研究表明，放射性与甲状腺选择性相关。初步研究表明，MHT具有抗甲状腺激素活性，因为它会降低大鼠血清中的甲状腺素。

Jones A R, Mashford P M

Xenobiotica. 1983 Feb;13(2):73-9. doi: 10.3109/00498258309052239.

The fate of N-methyl-N'-(hydroxy[14C]methyl)thiourea (MHT) has been studied in the male Sprague-Dawley rat. The compound is degraded to N-methylthiourea and formaldehyde. 2. N-Methylthiourea is excreted as a urinary metabolite whereas the formaldehyde is not excreted, either in the urine or the expired air, but is metabolized via formate to CO2. 3. At least 50% of an i.p. dose (100 mg/kg) of MHT is excreted unchanged and some of this undergoes hydrolysis within the urine to N-methylthiourea and formaldehyde. Production of formaldehyde leads to the formation of the urinary artefact N-(hydroxymethyl)urea. 4. Tissue-distribution studies with 14C-MHT have shown that radioactivity is selectively associated with the thyroid gland. A preliminary investigation has indicated that MHT has anti-thyroid hormone activity as it lowers the thyroxine in rat serum.

已在雄性斯普拉格 - 道利大鼠中研究了N - 甲基 - N' -（羟基[¹⁴C]甲基）硫脲（MHT）的代谢情况。该化合物降解为N - 甲基硫脲和甲醛。2. N - 甲基硫脲作为尿液代谢产物排出，而甲醛既不通过尿液也不通过呼出气体排出，而是通过甲酸代谢为二氧化碳。3. 腹腔注射剂量为100 mg/kg的MHT中，至少50%以原形排出，其中一些在尿液中水解为N - 甲基硫脲和甲醛。甲醛的产生导致尿液中出现人为产物N -（羟甲基）脲。4. 用¹⁴C - MHT进行的组织分布研究表明，放射性与甲状腺选择性相关。初步研究表明，MHT具有抗甲状腺激素活性，因为它会降低大鼠血清中的甲状腺素。