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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Mashford P M, Jones A R

Xenobiotica. 1982 Feb;12(2):119-24. doi: 10.3109/00498258209046785.

The metabolism of [14C]formaldehyde has been investigated in the male Sprague-Dawley rat. It is extensively oxidized to CO2 and formate, which is excreted in the urine. 2. Two radioactive compounds isolated from the urine of rats dosed with [14C]formaldehyde have been identified as N-hydroxymethylurea and N,N'-bis-(hydroxymethyl)urea, and shown to be urinary artefacts. 3. Previous studies of the metabolism of formaldehyde by rats have been re-appraised. Differences in the rate of oxidation of formaldehyde in various strains of rats result in the excretion of different urinary metabolites and, in some cases, formaldehyde. Excretion of formaldehyde leads to the formation of several artefacts depending on the components present in the urine.

已对雄性斯普拉格-道利大鼠体内[14C]甲醛的代谢进行了研究。它会被广泛氧化为二氧化碳和甲酸，后者经尿液排出。2. 从用[14C]甲醛给药的大鼠尿液中分离出的两种放射性化合物已被鉴定为N-羟甲基脲和N,N'-双（羟甲基）脲，并被证明是尿液中的假象。3. 对先前关于大鼠甲醛代谢的研究进行了重新评估。不同品系大鼠体内甲醛氧化速率的差异导致不同尿液代谢产物甚至在某些情况下甲醛的排出。甲醛的排出会根据尿液中存在的成分导致几种假象的形成。

Mashford P M, Jones A R

Xenobiotica. 1982 Feb;12(2):119-24. doi: 10.3109/00498258209046785.

The metabolism of [14C]formaldehyde has been investigated in the male Sprague-Dawley rat. It is extensively oxidized to CO2 and formate, which is excreted in the urine. 2. Two radioactive compounds isolated from the urine of rats dosed with [14C]formaldehyde have been identified as N-hydroxymethylurea and N,N'-bis-(hydroxymethyl)urea, and shown to be urinary artefacts. 3. Previous studies of the metabolism of formaldehyde by rats have been re-appraised. Differences in the rate of oxidation of formaldehyde in various strains of rats result in the excretion of different urinary metabolites and, in some cases, formaldehyde. Excretion of formaldehyde leads to the formation of several artefacts depending on the components present in the urine.

已对雄性斯普拉格-道利大鼠体内[14C]甲醛的代谢进行了研究。它会被广泛氧化为二氧化碳和甲酸，后者经尿液排出。2. 从用[14C]甲醛给药的大鼠尿液中分离出的两种放射性化合物已被鉴定为N-羟甲基脲和N,N'-双（羟甲基）脲，并被证明是尿液中的假象。3. 对先前关于大鼠甲醛代谢的研究进行了重新评估。不同品系大鼠体内甲醛氧化速率的差异导致不同尿液代谢产物甚至在某些情况下甲醛的排出。甲醛的排出会根据尿液中存在的成分导致几种假象的形成。