Lane J M, Bora F W, Pleasure D
J Bone Joint Surg Am. 1978 Mar;60(2):197-203.
Utilizing a sciatic nerve-transection model in rats, we studied the collagen content of normal control nerves, the long-term collagen accummulation in the distal stump of the transected nerve, the content of collagen of the posterior tibial nerve distal to the transection, and the myofibrosis of the gastrocnemius muscle. The distal stump of the sciatic nerve accumulated significant amounts of collagen with time but the posterior tibial nerve at a distance from the site of transection showed no progressive collagen accumulation. The histologically evident myofibrosis of the denervated gastrocnemius muscle was shown to be the result of a selective loss of muscle elements and not of an accumulation of collagen. cis-Hydroxyproline, a proline analogue, limited neuroma formation following neurorrhaphy. The findings suggest that the results of delayed repair of nerves should not be impaired by intraneural scarring if enough of the transected nerve beyond the point of intraneural scar formation is resected.
利用大鼠坐骨神经横断模型，我们研究了正常对照神经的胶原蛋白含量、横断神经远端残端胶原蛋白的长期积累、横断部位远端胫后神经的胶原蛋白含量以及腓肠肌的肌纤维化。坐骨神经远端残端的胶原蛋白随时间大量积累，但距横断部位一定距离的胫后神经未显示出胶原蛋白的渐进性积累。组织学上明显的失神经支配腓肠肌肌纤维化被证明是肌肉成分选择性丧失的结果，而非胶原蛋白积累的结果。脯氨酸类似物顺式羟脯氨酸限制了神经缝合术后神经瘤的形成。研究结果表明，如果切除神经内瘢痕形成点以外足够多的横断神经，神经延迟修复的结果不应受到神经内瘢痕形成的影响。
