Rönnberg L, Ylikorkala O
Int J Androl. 1983 Jun;6(3):235-9. doi: 10.1111/j.1365-2605.1983.tb00537.x.
The effect of the concomitant use of bromocriptine and clomiphene on pituitary function was tested in 8 healthy men, who ingested either 100 mg of clomiphene, 5 mg of bromocriptine or 100 mg of clomiphene +5 mg of bromocriptine daily for 7 days. Plasma concentrations of FSH and LH increased similarly during clomiphene and clomiphene + bromocriptine intake. Bromocriptine decreased the plasma levels of prolactin (Prl) and this decrease was unaffected by clomiphene. The latter blunted the plasma LH response to LHRH whilst bromocriptine blunted the Prl response to TRH, but Clomiphene and bromocriptine together had no additive effects on gonadotrophin and Prl secretion. It thus seems likely that this combination offers no advantage over clomiphene alone in the treatment of normoprolactinaemic infertile men.
在8名健康男性中测试了同时使用溴隐亭和克罗米芬对垂体功能的影响，这些男性每天服用100毫克克罗米芬、5毫克溴隐亭或100毫克克罗米芬 + 5毫克溴隐亭，持续7天。在服用克罗米芬和克罗米芬 + 溴隐亭期间，血浆促卵泡生成素（FSH）和促黄体生成素（LH）浓度的升高情况相似。溴隐亭降低了血浆催乳素（Prl）水平，且这种降低不受克罗米芬的影响。克罗米芬减弱了血浆LH对促性腺激素释放激素（LHRH）的反应，而溴隐亭减弱了Prl对促甲状腺激素释放激素（TRH）的反应，但克罗米芬和溴隐亭联合使用对促性腺激素和Prl分泌没有相加作用。因此，在治疗血催乳素正常的不育男性时，这种联合用药似乎并不比单独使用克罗米芬更具优势。
