Van der Auwera P, Schuyteneer F
J Antimicrob Chemother. 1983 Jun;11(6):511-5. doi: 10.1093/jac/11.6.511.
In-vitro, activities of gentamicin, tobramycin, netilmicin, amikacin, cefsulodin, latamoxef (moxalactam), carbenicillin, ticarcillin and piperacillin were compared against 147 randomly selected strains of Pseudomonas aeruginosa. Tobramycin was the most active aminoglycoside (MIC 90:4 mg/l), complete cross resistance with gentamicin (MIC 90:8 mg/l) was observed. Amikacin was the best alternative aminoglycoside (MIC 90:12 mg/l) Netilmicin showed only moderate activity (MIC 90:16 mg/l). Cefsulodin was the most active beta-lactam antibiotic (MIC 90:8 mg/l) but significant cross-resistance was observed with ticarcillin (MIC 90:32 mg/l) and piperacillin (MIC 90:12 micrograms/ml). Carbenicillin was two dilutions less active than ticarcillin, latamoxef showed a good activity (MIC 90:64 mg/l). Having the highest ratio between serum achievable concentration and MIC 90, piperacillin could be the best alternative drug to the aminoglycosides, of the tested antibiotics.
在体外实验中，比较了庆大霉素、妥布霉素、奈替米星、阿米卡星、头孢磺啶、拉氧头孢（羟羧氧酰胺菌素）、羧苄西林、替卡西林和哌拉西林对147株随机选择的铜绿假单胞菌的活性。妥布霉素是活性最强的氨基糖苷类药物（MIC90：4毫克/升），观察到与庆大霉素完全交叉耐药（MIC90：8毫克/升）。阿米卡星是最佳的替代氨基糖苷类药物（MIC90：12毫克/升），奈替米星仅表现出中等活性（MIC90：16毫克/升）。头孢磺啶是活性最强的β-内酰胺类抗生素（MIC90：8毫克/升），但观察到与替卡西林（MIC90：32毫克/升）和哌拉西林（MIC90：12微克/毫升）有显著交叉耐药。羧苄西林的活性比替卡西林低两个稀释度，拉氧头孢表现出良好的活性（MIC90：64毫克/升）。在受试抗生素中，哌拉西林的血清可达到浓度与MIC90之比最高，可能是氨基糖苷类药物的最佳替代药物。
