Kumar A J, Kuhajda F P, Martinez C R, Fishman E K, Jezic D V, Siegelman S S
J Comput Assist Tomogr. 1983 Oct;7(5):857-65. doi: 10.1097/00004728-198310000-00020.
Computed tomography was obtained in 15 patients with extracranial nerve sheath tumors, including eight with neurofibromatosis. The studies included two schwannomas, six neurofibromas, four plexiform neurofibromas, and three neurofibrosarcomas. Lesions with attenuation values exceeding 30 Hounsfield units had dense bands of collagen in resected specimens. Eleven of the lesions had attenuation values which were significantly lower than muscle. Histological examination of hypodense lesions revealed five factors contributing to reduced attenuation values: (a) a population of lipid-rich Schwann cells; (b) the presence of adipocytes (transformed fibroblasts) in neurofibromas; (c) entrapment of perineural adipose tissue by plexiform neurofibromas; (d) a coalescence of interstitial fluid to form cystic spaces in schwannoma with Antoni B tissue; and (e) cystic degeneration secondary to infarction or necrosis within neurofibromas and neurofibrosarcomas.
对15例颅外神经鞘瘤患者进行了计算机断层扫描，其中8例患有神经纤维瘤病。研究包括2例施万细胞瘤、6例神经纤维瘤、4例丛状神经纤维瘤和3例神经纤维肉瘤。切除标本中衰减值超过30亨氏单位的病变有致密的胶原带。11个病变的衰减值明显低于肌肉。对低密度病变的组织学检查揭示了导致衰减值降低的五个因素：(a)富含脂质的施万细胞群体；(b)神经纤维瘤中存在脂肪细胞（转化的成纤维细胞）；(c)丛状神经纤维瘤包绕神经周围脂肪组织；(d)间质液合并形成具有Antoni B组织的施万细胞瘤中的囊腔；(e)神经纤维瘤和神经纤维肉瘤内梗死或坏死继发的囊性变。
