Coleman B G, Arger P H, Dalinka M K, Obringer A C, Raney B R, Meadows A T
AJR Am J Roentgenol. 1983 Feb;140(2):383-7. doi: 10.2214/ajr.140.2.383.
Neurofibromatosis is a relatively common disorder that often involves many organ systems. One of the least understood aspects of this malady is a well documented potential for sarcomatous degeneration of neurofibromas. The inability to identify patients at risk and the lack of noninvasive screening methods for symptomatic patients often leads to late diagnosis. In six of seven subsequently proven neurofibrosarcomas, CT demonstrated low-density areas that histopathologically appeared to be due to necrosis, hemorrhage, and/or cystic degeneration. The density differences within these sarcomas were enhanced by the intravenous administration of iodinated contrast agents.
神经纤维瘤病是一种相对常见的疾病，常累及多个器官系统。这种疾病最不为人所了解的方面之一是，神经纤维瘤有恶变成为肉瘤的可能性，这一点已有充分记录。无法识别有风险的患者，以及缺乏针对有症状患者的非侵入性筛查方法，常常导致诊断延迟。在随后确诊的7例神经纤维肉瘤中，有6例CT显示出低密度区域，组织病理学检查显示这些区域似乎是由坏死、出血和/或囊性变引起的。静脉注射碘化造影剂后，这些肉瘤内的密度差异更加明显。
