Idé C, Munger B L
J Comp Neurol. 1978 May 15;179(2):301-24. doi: 10.1002/cne.901790205.
The developmental sequence of Grandry corpuscles was traced in the toe skin of embryonic, young and adult chickens by light and electron microscopy. The developing Grandry cells as well as Schwann cells can first be identified at stage 38 (approximately 12 days of incubation) due to the cytoplasmic content of scattered secretory granules of approximately 100 nm in diameter. Such developing Grandry cells are always associated with nerve fibers. During late stages (stages 40-42, 14-16 days of incubation) several immature Grandry cells formed cell clusters in the dermis. Such cell clusters were always in contact with growing nerve tips of Schwann cells. Immature Grandry cells were separated from one another and dispersed in the connective tissue compartment at stages 44-45 (near hatching). By the time of hatching the developing Grandry cells began to have the morphological characteristics of adult cells. They were relatively large in cell diameter (approximately 10 micron) containing numerous secretory granules and bundles of filamentous material. These cells had finger-like cytoplasmic processes. The Grandry cells at this time had an intimate relationship with nerve fibers and satellite cells. The fact that Grandry cells were always associated with nerve fibers throughout development would support the hypothesis that Grandry cells are derived from neural elements, perhaps neural crest. Satellite cells of Grandry corpuscles are apparently derived from Schwann cells. Grandry cells and corpuscles are adult in form by two to three months of age.
通过光学显微镜和电子显微镜，对胚胎期、幼年期及成年期鸡的趾部皮肤中格兰德里小体的发育序列进行了追踪。在胚胎发育第38阶段（约孵化12天），由于直径约100纳米的散在分泌颗粒的细胞质内容物，发育中的格兰德里细胞以及施万细胞首次得以识别。此类发育中的格兰德里细胞总是与神经纤维相关联。在发育后期（第40 - 42阶段，孵化14 - 16天），几个未成熟的格兰德里细胞在真皮中形成细胞簇。此类细胞簇总是与施万细胞的生长神经末梢相接触。在第44 - 45阶段（接近孵化时），未成熟的格兰德里细胞彼此分离并分散在结缔组织隔室中。到孵化时，发育中的格兰德里细胞开始具备成年细胞的形态特征。它们的细胞直径相对较大（约10微米），含有大量分泌颗粒和成束的丝状物质。这些细胞具有指状细胞质突起。此时的格兰德里细胞与神经纤维和卫星细胞关系密切。格兰德里细胞在整个发育过程中始终与神经纤维相关联这一事实，支持了格兰德里细胞源自神经成分（或许是神经嵴）的假说。格兰德里小体的卫星细胞显然源自施万细胞。格兰德里细胞和小体在两到三个月大时形态发育成熟。
