Sandage B W, Fletcher H P
Pharmacology. 1983;27(2):110-6. doi: 10.1159/000137842.
Single intraperitoneal doses of phenylephrine (PE), phenylpropanolamine (PPA) and pseudoephedrine (PSD) have differing effects on blood glucose in stressed, normal and goldthioglucose (GTG) mice. PE in normal and GTG mice caused a pronounced but temporary rise in blood glucose while PPA failed to show a significant effect on resting blood glucose in either animal. PSD, in normal and GTG mice, caused a hyperglycemia at 2 h after treatment. Reduced stress conditions (nonrepeated orbital sinus blood sampling) or adrenalectomy eliminated the PSD delayed hyperglycemia in normal mice. PSD did not alter immunoreactive insulin levels at 2 h; however, PSD caused significantly higher corticosterone levels in normal and GTG mice at 2 h. PPA, which did not cause hyperglycemia, had no effect on corticosterone levels at 2 h in normal mice.
腹腔注射单剂量的去氧肾上腺素（PE）、苯丙醇胺（PPA）和伪麻黄碱（PSD），对应激小鼠、正常小鼠和金硫葡萄糖（GTG）小鼠的血糖有不同影响。在正常小鼠和GTG小鼠中，PE可导致血糖显著但短暂升高，而PPA对这两种小鼠的静息血糖均无显著影响。在正常小鼠和GTG小鼠中，PSD在给药后2小时引起高血糖。减轻应激条件（非重复眶窦采血）或肾上腺切除可消除正常小鼠中PSD延迟出现的高血糖。PSD在2小时时未改变免疫反应性胰岛素水平；然而，PSD在2小时时使正常小鼠和GTG小鼠的皮质酮水平显著升高。未引起高血糖的PPA对正常小鼠2小时时的皮质酮水平无影响。
