Jura W G, Brown C G, Rowland A C
Vet Parasitol. 1983 May;12(2):115-34. doi: 10.1016/0304-4017(83)90001-8.
Host-parasite relationships have been studied by electron microscopy using glutaraldehyde-OsO4-fixed pellets of lymphoid cultures infected in vitro by Theileria annulata and T. parva. Intracellular presence of the parasite resulted in a progressive and marked lymphoblastoid transformation. The schizont stage periodically provoked the formation of, and adopted an intimate association with, cytoplasmic annulate lamellae in the interphase cell. Annulate lamellae developed from the outer nuclear membrane of the host cell by a delamination process and were taken into the cytoplasmic matrix of the schizont by phagotrophy through the cytostome. Schizont nuclei themselves were seen to divide at the prometaphase stage of host cell mitosis, the division being characterized by the development of intranuclear spindle microtubules anchored in spindle pole bodies. A hypothesis is propounded that Theileria parasites, consequent on interiorization, provoke the blastoid transformation and the formation of annulate lamellae through the influence of components of their genomic material on host cell deoxyribonucleic acid (DNA) and that the annulate lamellae represent a species of messenger ribonucleic acid (mRNA) and serve as a monitoring device for the schizont, facilitating the accurate timing of the host cell cyclical events.
利用戊二醛 - 四氧化锇固定的、经环形泰勒虫和微小泰勒虫体外感染的淋巴样培养物沉淀，通过电子显微镜对宿主 - 寄生虫关系进行了研究。寄生虫在细胞内的存在导致了渐进性且显著的成淋巴细胞样转化。裂殖体阶段周期性地引发间期细胞中胞质环层板的形成，并与之形成紧密关联。环层板通过分层过程从宿主细胞的外核膜发育而来，并通过胞口经吞噬作用被摄取到裂殖体的细胞质基质中。裂殖体细胞核在宿主细胞有丝分裂的前中期阶段进行分裂，这种分裂的特征是在纺锤极体中锚定的核内纺锤体微管的发育。有人提出一种假说，即泰勒虫寄生虫内化后，通过其基因组物质的成分对宿主细胞脱氧核糖核酸（DNA）的影响，引发胚样转化和环层板的形成，并且环层板代表一种信使核糖核酸（mRNA），作为裂殖体的监测装置，促进宿主细胞周期事件的精确计时。
