Ge K, Xue A, Bai J, Wang S
Virchows Arch A Pathol Anat Histopathol. 1983;401(1):1-15. doi: 10.1007/BF00644785.
Keshan disease, an endemic cardiomyopathy in China, was prevalent in rural areas located in a long belt region where the selenium content was low in foods. Intervention studies with well controlled subjects revealed a prophylactic effect of sodium selenite. Multifocal necrosis and fibrous replacement of the myocardium characterized the histopathological features and myocytolysis was present in most cases. Ultrastructural observations on twelve postmortem cases revealed remarkable changes in many organelles of which mitochondria appeared to be most important in the development of myocardial lesions. Three kinds of specific granules, which have not been found in other reports on cardiomyopathies, were represented and other factors which might also contribute to the aetiology are discussed.
克山病是中国的一种地方性心肌病，在食物中硒含量低的长带状农村地区流行。对受试者进行严格对照的干预研究显示亚硒酸钠有预防作用。心肌的多灶性坏死和纤维性替代是其组织病理学特征，大多数病例存在心肌溶解。对12例尸检病例的超微结构观察发现许多细胞器有显著变化，其中线粒体在心肌病变发展中似乎最为重要。文中呈现了三种在其他心肌病报告中未发现的特殊颗粒，并讨论了可能也与病因有关的其他因素。
