Yoshinari M, Okamura K, Tokuyama T, Shiroozu A, Nakashima T, Inoue K, Omae T
Br Med J (Clin Res Ed). 1983 Sep 10;287(6394):720-2. doi: 10.1136/bmj.287.6394.720.
Twenty seven hypothyroid patients with a serum concentration of thyroid stimulating hormone (TSH) of over 40 mU/1 were followed up for three to 20 weeks without replacement therapy. The serum thyroid hormone concentrations increased with a dramatic decrease in serum TSH values in 14 patients (reversible group) but there was no significant change in the other 13 (irreversible group). Fourteen out of 19 patients with goitre but none of the eight patients without goitre belonged to the reversible group. All of the 11 patients with a high uptake of iodide by the thyroid, three of the six with a normal uptake, and none of the 10 with a low uptake belonged to the reversible group. These observations indicate that patients with goitrous hypothyroidism with a preserved thyroid uptake of iodide are likely to become euthyroid spontaneously without replacement therapy.
对27例血清促甲状腺激素（TSH）浓度超过40 mU/1的甲状腺功能减退患者进行了为期3至20周的随访，期间未进行替代治疗。14例患者（可逆组）血清甲状腺激素浓度升高，血清TSH值显著下降，而另外13例患者（不可逆组）则无显著变化。19例甲状腺肿患者中有14例属于可逆组，而8例无甲状腺肿患者中无一例属于可逆组。甲状腺碘摄取率高的11例患者全部属于可逆组，碘摄取率正常的6例患者中有3例属于可逆组，碘摄取率低的10例患者中无一例属于可逆组。这些观察结果表明，甲状腺肿性甲状腺功能减退且甲状腺碘摄取功能保留的患者，在不进行替代治疗的情况下有可能自发恢复甲状腺功能正常。
