Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and ornithine decarboxylase activity by quercetin: possible involvement of lipoxygenase inhibition.
作者信息
Kato R, Nakadate T, Yamamoto S, Sugimura T
出版信息
Carcinogenesis. 1983 Oct;4(10):1301-5. doi: 10.1093/carcin/4.10.1301.
PMID:6413085
Abstract
Quercetin (30 mumol/mouse) markedly suppressed the effect of 12-O-tetradecanoylphorbol-13-acetate (TPA, 20 nmol/mouse) on skin tumor formation in the CD-1 mice initiated by 7,12-dimethylbenz[a]anthracene (200 nmol/mouse). TPA (20 nmol/mouse)-induced epidermal ornithine decarboxylase (ODC) activity was also inhibited by quercetin (10-30 mumol/mouse), but it failed to inhibit the stimulation of epidermal DNA synthesis by TPA. In addition, quercetin potently inhibited lipoxygenase from 105 000 g supernatant of epidermal homogenate of mice. The 50% inhibition of lipoxygenase was observed by quercetin at 1.3 microM. These results suggest that the inhibition of lipoxygenase by quercetin is one of the major actions of the above agent to inhibit tumor promotion and TPA-induced ODC activity.
摘要
相似文献
1
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and ornithine decarboxylase activity by quercetin: possible involvement of lipoxygenase inhibition.
Carcinogenesis. 1983 Oct;4(10):1301-5. doi: 10.1093/carcin/4.10.1301.
3
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity by lipoxygenase inhibitors: possible role of product(s) of lipoxygenase pathway.脂氧合酶抑制剂对12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯诱导的表皮鸟氨酸脱羧酶活性的抑制作用：脂氧合酶途径产物的可能作用
Carcinogenesis. 1982;3(12):1411-4. doi: 10.1093/carcin/3.12.1411.
4
5
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-mediated epidermal ornithine decarboxylase induction and skin tumor promotion by new lipoxygenase inhibitors lacking protein kinase C inhibitory effects.
Carcinogenesis. 1986 Nov;7(11):1809-12. doi: 10.1093/carcin/7.11.1809.
6
Inhibition by lipoxygenase inhibitors of 7-bromomethylbenz[a]anthracene-caused epidermal ornithine decarboxylase induction and skin tumor promotion in mice.脂氧合酶抑制剂对7-溴甲基苯并[a]蒽诱导小鼠表皮鸟氨酸脱羧酶及皮肤肿瘤促进作用的抑制
Carcinogenesis. 1989 Nov;10(11):2053-7. doi: 10.1093/carcin/10.11.2053.
7
8
[Factors controlling tumor promotion induced by TPA].
Gan To Kagaku Ryoho. 1986 Mar;13(3 Pt 2):782-9.
9
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity and tumor promotion by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) in mouse skin.N-(6-氨基己基)-5-氯-1-萘磺酰胺（W-7）对小鼠皮肤中12-O-十四酰佛波醇-13-乙酸酯诱导的表皮鸟氨酸脱羧酶活性及肿瘤促进作用的抑制
Pharmacology. 1986;32(3):167-75. doi: 10.1159/000138166.
10
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced increase in vascular permeability in mouse skin by lipoxygenase inhibitors.
Jpn J Pharmacol. 1985 Jun;38(2):161-8. doi: 10.1254/jjp.38.161.
引用本文的文献
1
Molecular Targets Underlying the Anticancer Effects of Quercetin: An Update.槲皮素抗癌作用的分子靶点：最新进展
Nutrients. 2016 Aug 29;8(9):529. doi: 10.3390/nu8090529.
2
Linalool Induces Cell Cycle Arrest and Apoptosis in Leukemia Cells and Cervical Cancer Cells through CDKIs.芳樟醇通过细胞周期蛋白依赖性激酶抑制剂诱导白血病细胞和宫颈癌细胞的细胞周期阻滞和凋亡。
Int J Mol Sci. 2015 Nov 26;16(12):28169-79. doi: 10.3390/ijms161226089.
3
Quercetin enhances tumorigenicity induced by N-ethyl-N'-nitro-N-nitrosoguanidine in the duodenum of mice.槲皮素增强 N-乙基-N'-硝基-N-亚硝基胍在小鼠十二指肠诱导的肿瘤发生。
Environ Health Prev Med. 2002 Jan;6(4):235-9. doi: 10.1007/BF02897975.
4
Quercetin potentiates UVB-Induced c-Fos expression: implications for its use as a chemopreventive agent.槲皮素增强 UVB 诱导的 c-Fos 表达：其作为化学预防剂的应用。
Cancer Prev Res (Phila). 2010 Jul;3(7):876-84. doi: 10.1158/1940-6207.CAPR-09-0220. Epub 2010 Jun 15.
5
Cancer-relevant biochemical targets of cytotoxic Lonchocarpus flavonoids: a molecular docking analysis.细胞毒性厚鳞柯黄酮的癌症相关生化靶标：分子对接分析。
J Mol Model. 2010 Feb;16(2):311-26. doi: 10.1007/s00894-009-0547-5. Epub 2009 Jul 15.
6
Red wine polyphenols for cancer prevention.红葡萄酒多酚预防癌症。
Int J Mol Sci. 2008 May;9(5):842-853. doi: 10.3390/ijms9050842. Epub 2008 May 20.
7
Anticarcinogenic compounds in the Uzbek medicinal plant, Helichrysum maracandicum.
J Nat Med. 2008 Apr;62(2):174-8. doi: 10.1007/s11418-007-0223-y. Epub 2008 Jan 16.
8
Carcinogenicity of food mutagens.食品诱变剂的致癌性。
Environ Health Perspect. 1996 May;104 Suppl 3(Suppl 3):429-33. doi: 10.1289/ehp.96104s3429.
9
Inhibitory effects of inhibitors of arachidonic acid metabolism on the evolution of rat liver preneoplastic foci into nodules and hepatocellular carcinomas with or without phenobarbital exposure.花生四烯酸代谢抑制剂对大鼠肝脏癌前病灶演变为结节及肝细胞癌的抑制作用，有无苯巴比妥暴露情况均涉及。
Jpn J Cancer Res. 1993 Feb;84(2):120-7. doi: 10.1111/j.1349-7006.1993.tb02844.x.
10
Cell culture assays for chemicals with tumor-promoting or tumor-inhibiting activity based on the modulation of intercellular communication.基于细胞间通讯调节的具有促肿瘤或抑肿瘤活性化学物质的细胞培养分析。
Cell Biol Toxicol. 1994 Apr;10(2):71-116. doi: 10.1007/BF00756491.
Zotero 插件