氨茶碱对新生仔猪脑血流的影响。

Effect of aminophylline on brain blood flow in the newborn piglet.

作者信息

Stonestreet B S, Nowicki P T, Hansen N B, Petit R, Oh W

出版信息

Dev Pharmacol Ther. 1983;6(4):248-58. doi: 10.1159/000457311.

Abstract

The effect of 6 mg/kg of aminophylline on brain blood flow was examined in newborn piglets. Arterial plasma aminophylline concentration averaged 7 mg/l. Total brain, regional brain (cerebrum, cerebellum and stem) and eye blood flow as well as the total brain oxygen consumption were not altered by aminophylline treatment. Choroid plexus blood flow was five times higher than the total brain blood flow in these newborn piglets. In contrast to brain blood flow, choroid plexus blood flow decreased significantly following aminophylline administration.

摘要

在新生仔猪中研究了6毫克/千克氨茶碱对脑血流的影响。动脉血浆氨茶碱浓度平均为7毫克/升。氨茶碱治疗未改变全脑、脑局部区域（大脑、小脑和脑干）及眼部血流，也未改变全脑氧耗。在这些新生仔猪中，脉络丛血流比全脑血流高五倍。与脑血流不同，氨茶碱给药后脉络丛血流显著降低。