Wijngaards G, Jespersen J
Eur J Clin Invest. 1983 Aug;13(4):347-50. doi: 10.1111/j.1365-2362.1983.tb00111.x.
Biopsies of the gastric mucosa were collected from two patients with Ménétrièr's disease before, during, and after treatment with cimetidine and studied for fibrinolytic activity. The fibrinolytic activity in the homogenates or in the potassium thiocyanate soluble fractions increased markedly during the treatment. Immunological characterization of the activity indicated that its major component was an endothelium-derived type of plasminogen activator, and that the increase in activity was caused solely by an increase in the concentration of this component. This suggests an increase in the vascularity of the mucosal layers during treatment thus reflecting a repair process.
从两名患有梅内特里尔病的患者身上，在西咪替丁治疗前、治疗期间和治疗后采集胃黏膜活检样本，并对其纤溶活性进行研究。在治疗期间，匀浆或硫氰酸钾可溶部分中的纤溶活性显著增加。对该活性的免疫学特征分析表明，其主要成分是一种内皮源性纤溶酶原激活物类型，且活性增加完全是由该成分浓度的增加所致。这表明治疗期间黏膜层血管化增加，从而反映了一个修复过程。
