Debeer L J, Mannaerts G P
Diabete Metab. 1983 May-Jun;9(2):134-40.
In this brief review a survey is presented of our present knowledge of mitochondrial and peroxisomal fatty acid oxidation. For mitochondrial fatty acid oxidation, emphasis is placed on the key regulatory role of the carnitine acyltransferase system and its modulation by malonyl-Co-A. Also, the concept of opposite regulation of fatty acid synthesis and oxidation in response to nutritional or hormonal stimuli is presented. For peroxisomal fatty acid oxidation, the key features of the system are summarized together with various approaches used to measure the contribution of the peroxisomal pathway to overall fatty acid oxidation. The conclusion is reached that this contribution is minor, at least for the most abundant fatty acids palmitate and oleate.
在这篇简短的综述中，我们概述了目前对线粒体和过氧化物酶体脂肪酸氧化的认识。对于线粒体脂肪酸氧化，重点介绍了肉碱酰基转移酶系统的关键调节作用及其受丙二酸单酰辅酶A的调节。此外，还阐述了在营养或激素刺激下，脂肪酸合成与氧化的反向调节概念。对于过氧化物酶体脂肪酸氧化，总结了该系统的关键特征以及用于测量过氧化物酶体途径对整体脂肪酸氧化贡献的各种方法。得出的结论是，至少对于最丰富的脂肪酸棕榈酸酯和油酸酯来说，这种贡献较小。
