Voshaar T, Hess K M, Pfeiffer P, Theobald K, Szperalski B, Bohn A, König W
Immun Infekt. 1983 Mar;11(2):39-45.
Recent developments as to the IgE-antibody synthesis in rodents and in the human model are summarized and discussed in reference to our own data. It is by now established that the IgE-antibody response is regulated by interdependent interactions of cellular, humoral and genetic factors. The IgE-bearing B-lymphocyte develops from a surface IgM carrying B-lymphocyte. The transformation into an IgE secreting plasma cell requires T-cell help or soluble T-cell factors. Recent advances in the characterization of human lymphocytes as well as more sophisticated cell biological approaches facilitated the analysis of IgE-antibody synthesis in the human in vitro model. In most of the studies at present available the effect of the polyclonal B-cell mitogen (PWM) was analyzed. PWM either enhanced, suppressed or unlike to other Ig-classes did not affect the IgE-antibody synthesis at all. Immunotherapeutic approaches have to consider to establish the allergen induced in vitro model of IgE-antibody synthesis in humans, to modulate the interactions of T-helper and/or suppressor cells or to generate soluble suppressor factors. In any case the analysis of the IgE-antibody synthesis in humans could be a valuable tool to assess IgE-B-cell memory towards various allergens and to determine the IgE-mediated in patients.
结合我们自己的数据，总结并讨论了在啮齿动物和人类模型中IgE抗体合成的最新进展。目前已经确定，IgE抗体反应受细胞、体液和遗传因素的相互依赖相互作用调节。携带IgE的B淋巴细胞由携带表面IgM的B淋巴细胞发育而来。转化为分泌IgE的浆细胞需要T细胞的帮助或可溶性T细胞因子。人类淋巴细胞表征方面的最新进展以及更复杂的细胞生物学方法促进了对人类体外模型中IgE抗体合成的分析。在目前可用的大多数研究中，分析了多克隆B细胞有丝分裂原（PWM）的作用。PWM要么增强、抑制IgE抗体合成，要么与其他Ig类不同，根本不影响IgE抗体合成。免疫治疗方法必须考虑建立人类IgE抗体合成的变应原诱导体外模型，调节辅助性T细胞和/或抑制性T细胞的相互作用，或产生可溶性抑制因子。在任何情况下，对人类IgE抗体合成的分析都可能是评估IgE-B细胞对各种变应原的记忆以及确定患者中IgE介导情况的有价值工具。
