杀菌阳离子蛋白1和2的抗菌活性，兔肺巨噬细胞的天然肽抗生素。
Antibacterial activity of microbicidal cationic proteins 1 and 2, natural peptide antibiotics of rabbit lung macrophages.
作者信息
Lehrer R I, Selsted M E, Szklarek D, Fleischmann J
出版信息
Infect Immun. 1983 Oct;42(1):10-4. doi: 10.1128/iai.42.1.10-14.1983.
Abstract
Microbicidal cationic proteins 1 and 2, peptides derived from rabbit lung macrophages, were tested for bactericidal activity against various bacterial species. Both were highly active against diverse gram-positive and gram-negative organisms under conditions of near-neutral pH (between 7 and 8) and relatively low ionic strength. Susceptible species included Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Listeria monocytogenes, Pseudomonas aeruginosa, Klebsiella pneumoniae, Haemophilus influenzae, Escherichia coli, and Serratia marcescens. Streptococcus agalactiae, type 1A, was less susceptible than the aforementioned organisms or S. agalactiae, type 3. Bordetella bronchiseptica, a common commensal and pathogen of the rabbit respiratory tract, was completely resistant to both peptides.
摘要
对源自兔肺巨噬细胞的杀菌阳离子蛋白1和2这两种肽进行了针对多种细菌的杀菌活性测试。在接近中性pH（7至8之间）和相对低离子强度的条件下，二者对多种革兰氏阳性菌和革兰氏阴性菌均具有高活性。易感菌种包括金黄色葡萄球菌、表皮葡萄球菌、肺炎链球菌、单核细胞增生李斯特菌、铜绿假单胞菌、肺炎克雷伯菌、流感嗜血杆菌、大肠杆菌和粘质沙雷氏菌。1A型无乳链球菌比上述菌种或3型无乳链球菌更不易感。支气管败血波氏杆菌是兔呼吸道常见的共生菌和病原体，对这两种肽均完全耐药。
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