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In vitro activity of A-56268 (TE-031), a new macrolide, compared with that of erythromycin and clindamycin against selected gram-positive and gram-negative organisms.新型大环内酯类药物A-56268（TE-031）与红霉素和克林霉素相比，对所选革兰氏阳性菌和革兰氏阴性菌的体外活性。
Antimicrob Agents Chemother. 1987 Feb;31(2):328-30. doi: 10.1128/AAC.31.2.328.
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Susceptibility of Legionella pneumophila to twenty antimicrobial agents.嗜肺军团菌对二十种抗菌药物的敏感性
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Antimicrobial activity of several antibiotics and a sulfonamide against Chlamydia trachomatis organisms in cell culture.几种抗生素及一种磺胺类药物在细胞培养中对沙眼衣原体的抗菌活性。
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新型大环内酯类药物A-56268（TE-031）与红霉素和克林霉素相比，对所选革兰氏阳性菌和革兰氏阴性菌的体外活性。

In vitro activity of A-56268 (TE-031), a new macrolide, compared with that of erythromycin and clindamycin against selected gram-positive and gram-negative organisms.

作者信息

Benson C A, Segreti J, Beaudette F E, Hines D W, Goodman L J, Kaplan R L, Trenholme G M

出版信息

Antimicrob Agents Chemother. 1987 Feb;31(2):328-30. doi: 10.1128/AAC.31.2.328.

DOI:10.1128/AAC.31.2.328
PMID:2952063
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC174717/
Abstract

The in vitro activity of A-56268 was determined and compared with that of erythromycin and clindamycin against a limited spectrum of 401 gram-positive and gram-negative organisms. A-56268 was quite active against erythromycin-susceptible Staphylococcus aureus, Neisseria gonorrhoeae, Listeria monocytogenes, Streptococcus pneumoniae, Streptococcus pyogenes, and group B streptococci and was moderately active against Campylobacter fetus subsp. fetus. A-56268 was consistently bactericidal only for S. pneumoniae. The activity of A-56268 was comparable to that of erythromycin against most organisms tested.

摘要

测定了A - 56268对401株革兰氏阳性和革兰氏阴性菌的体外活性，并将其与红霉素和克林霉素进行了比较。A - 56268对红霉素敏感的金黄色葡萄球菌、淋病奈瑟菌、单核细胞增生李斯特菌、肺炎链球菌、化脓性链球菌和B组链球菌有较强活性，对胎儿弯曲菌胎儿亚种有中等活性。A - 56268仅对肺炎链球菌始终具有杀菌作用。A - 56268对大多数测试菌株的活性与红霉素相当。