Olsen C S, Scroggins H S
J Pharm Sci. 1983 Aug;72(8):963-5. doi: 10.1002/jps.2600720835.
A rapid, precise, sensitive, and specific assay for nitroglycerin in sublingual, sustained-release, and ointment dosage forms using high-performance liquid chromatography is described. The nitroglycerin dosage forms were dissolved in methanol, filtered, and injected directly into the liquid chromatograph. A variable-wavelength UV detector operated at 220 nm and a C18 microporous silica column were employed. The mobile phase was methanol-water (40:60).
本文描述了一种使用高效液相色谱法对舌下含服、缓释和软膏剂型中的硝酸甘油进行快速、精确、灵敏且特异的测定方法。硝酸甘油剂型溶解于甲醇中，过滤后直接注入液相色谱仪。采用在220 nm波长下操作的可变波长紫外检测器和C18微孔硅胶柱。流动相为甲醇 - 水（40:60）。
