类风湿关节炎中的甲状腺功能障碍：一项对照前瞻性调查。
Thyroid dysfunction in rheumatoid arthritis: a controlled prospective survey.
作者信息
Shiroky J B, Cohen M, Ballachey M L, Neville C
机构信息
Division of Rheumatology, Montreal General Hospital, Quebec, Canada.
出版信息
Ann Rheum Dis. 1993 Jun;52(6):454-6. doi: 10.1136/ard.52.6.454.
OBJECTIVES
To determine whether thyroid dysfunction is found with increased frequency in patients with rheumatoid arthritis (RA).
METHODS
A controlled prospective survey was conducted on a cohort of patients with RA derived from a hospital clinic and a private surburban rheumatology practice. A control group with similar demographic features was generated from the same sources and included subjects with either osteoarthritis or fibromyalgia. Consecutive patients were evaluated over a six month period. The evaluation included a complete history and physical examination, and determination of serum thyroxine, free thyroxine, triiodothyronine, thyroid stimulating hormone (IRMA), antinuclear antibodies, and rheumatoid factor.
RESULTS
Of the 91 women with RA evaluated, 29 (30%) had evidence of thyroid dysfunction compared with 10 (11%) of 93 controls. The excess thyroid dysfunction is due to either hypothyroidism or Hashimoto's thyroiditis and was independent of age, increasing duration of disease, rheumatoid factor, and antinuclear antibodies.
CONCLUSIONS
Thyroid dysfunction is seen at least three times more often in women with RA than in women with similar demographic features with non-inflammatory rheumatic diseases such as osteoarthritis and fibromyalgia.
目的
确定类风湿关节炎（RA）患者甲状腺功能障碍的发生频率是否增加。
方法
对来自医院门诊和一家私立郊区风湿病诊所的一组RA患者进行了一项对照前瞻性调查。从相同来源选取具有相似人口统计学特征的对照组，包括骨关节炎或纤维肌痛患者。在六个月的时间里对连续的患者进行评估。评估内容包括完整的病史和体格检查，以及血清甲状腺素、游离甲状腺素、三碘甲状腺原氨酸、促甲状腺激素（免疫放射测定法）、抗核抗体和类风湿因子的测定。
结果
在接受评估的91名RA女性患者中，29名（30%）有甲状腺功能障碍的证据，而93名对照组患者中有10名（11%）。甲状腺功能障碍过多是由于甲状腺功能减退或桥本甲状腺炎，且与年龄、病程延长、类风湿因子和抗核抗体无关。
结论
与患有骨关节炎和纤维肌痛等非炎性风湿性疾病且具有相似人口统计学特征的女性相比，RA女性中甲状腺功能障碍的发生率至少高出三倍。
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