胎鼠主动脉前列环素合成酶活性较低。出生后逐渐升高。

Low prostacyclin synthetase activity of fetal rat aorta. Progressive increase after birth.

作者信息

Deckmyn H, Font L, Van Hemelen C, Carreras L O, Defreyn G, Vermylen J

出版信息

Life Sci. 1983 Oct 10;33(15):1491-7. doi: 10.1016/0024-3205(83)90852-4.

Abstract

Aortae from fetal or 3 weeks old rats produced very small amounts of PGI2, prostacyclin. This production increased from 4 weeks on, reaching adult values at about ten weeks. This maturation seemed to be predominantly determined by a change in the PGI2 synthetase system, rather than in arachidonic acid availability, phospholipase or cyclo-oxygenase activity. The anti-oxidant ascorbic acid stimulated prostacyclin production more strongly in adult than in young rat aortae. This finding suggests that the lower production of PGI2 by young tissues is not due to an enhanced inhibition of prostacyclin synthetase by lipid peroxides.

摘要

来自胎儿或3周龄大鼠的主动脉产生的前列环素（PGI2）量非常少。从4周龄开始，这种产量增加，在大约10周时达到成年水平。这种成熟似乎主要由PGI2合成酶系统的变化决定，而不是由花生四烯酸的可用性、磷脂酶或环氧化酶活性决定。抗氧化剂抗坏血酸对成年大鼠主动脉中前列环素产生的刺激作用比对幼年大鼠主动脉的刺激作用更强。这一发现表明，年轻组织中PGI2产量较低并非由于脂质过氧化物对前列环素合成酶的抑制作用增强。